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  • As the United States aims to increase early diagnosis and treatment of people with HIV, a greater focus has been placed on determining the accuracy of HIV tests in real-world settings—not only to minimize the number of false positive or negative test results, but to better identify people during the early (acute) stages of infection when the risk of transmission is especially high.

    In order to do this, researchers from the University of California, San Francisco (UCSF) conducted a review of over 21,000 HIV tests performed between the years 2003 and 2008 in some of the city's high-prevalence populations.

    Of four types of tests used during this period—from first-generation antibody tests to rapid oral tests—761 people were diagnosed with HIV (3.6% prevalence), of which 58 were identified during acute infection.

    The study also aimed to compare the accuracy of newer testing assays—including fourth-generation antigen/antibody tests—by retesting the blood from the 58 people previously diagnosed with acute HIV infection.

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